Harmala alkaloids are most known for being reversible inhibitors the monoamine oxidase.

this is most appreciated through the synergies that exist with ayahuasca, a composite brew. containing harmine, harmaline (DHH), and tetrahydroharmine (THH), the ayahuasca vine, banisteriopsis caapi, makes DMT orally available which has also been combined in the brew through the plant Chacruna, Psychotria viridis.

While it enables DMT to be orally active, it also potentiates all tryptamines, including psilocybin, 4-PO-DMT. Harmalas serve to potentiate and deepen the qualitative experience beheld by the journier.

harmala’s have abundant sources in nature , as mentioned aya vine. it can also be found readily in passion flower vine. mostly its derived from Peganum Harmala, syrian rue, which is where its alkaloid namesake originates. While syrian rue has traditional uses and many harmala alkaloids, theres a means to fraction the alkaloids within. specifically isolating harmine and harmaline from the rest.

Bobinsana , caliandra augustifolia, is another ayahuasca additive that contains THH. Anecdotally THH may correlate to heightened sensation specifically hearing lending a potential mechanic to the phenomenon of icaors, traditional medicine songs.

Harmine is the most studied of all harmala alkaloids with wild efficacy to healing cancer, infections, parasites, pancreatic function, mood/consciousness, and more. Personally Ive had success in treating lyme, Ive also witnessed its impact in cancers and pancreas revivification in family and friends acquaintances.

harmaline, dihydroharmine, has gotten some attention and shows benefit in a wide range of applications as well. its notably the strongest in inhibiting the monoamine oxidase, about twice as effective as harmine. to be noted for dosing as excessive amounts of betacarbolines is rarely a pleasant experience

typically i take 100-130 mg of harmine/harmaline 3-5 x nightly for 1 up to 6 weeks depending on how intense of a cleanse im aiming for, now i dont exceed 3 weeks as Ive cleared the chronic pathologies.

i wouldnt advise takign more than 200mg harmaline as it is a potent drug and unnessary for most, it takes longer to recover from. whereas 200mg of harmine is a comfortable place. again harmine is half the potency as harmaline

Contraindications

MAOIs can potentially cause drug-to-drug interactions, drug-food interaction, and overdoses, of which the patient should be aware.[9] For example, patients should not be mixing MAOIs with other antidepressants like selective serotonin reuptake inhibitors (SSRIs).[12] These two drugs combined can cause serotonin syndrome, which is potentially fatal. The first cases of serotonin syndrome were reported during the 1960s when patients were on MAOIs and tryptophan. Patients showed signs and symptoms of fever, confusion, increased perspiration, muscle rigidity, seizures, liver or kidney problems, fluctuation of heart rhythms, and blood pressure. Furthermore, when changing MAOIs to another antidepressant, patients should give themselves 14 days to pass before initiating the new treatment, to prevent any drug interaction.

MAOIs prevent the breakdown of tyramine found in the body and certain foods, drinks, and other medications. Patients that take MAOIs and consume tyramine-containing foods or drinks will exhibit high serum tyramine level.[13][14] A high level of tyramine can cause a sudden increase in blood pressure, called the tyramine pressor response.[14] Even though it is rare, a high tyramine level can trigger a cerebral hemorrhage, which can even result in death.

Eating foods with high tyramine can trigger a reaction that can have serious consequences.[14] Patients should know that tyramine can increase with the aging of food; they should be encouraged to have fresh foods instead of leftovers or food prepared hours earlier.  Examples of high levels of tyramine in food are types of fish and types of meat, including sausage, turkey, liver, and salami.[15][16] Also, certain fruits can contain tyramine, like overripe fruits, avocados, bananas, raisins, or figs. Further examples are cheeses, alcohol, and fava beans; all of these should be avoided even after two weeks of stopping MAOIs.[16] Anyone taking MAOIs is at risk for an adverse hypertensive reaction, with accompanying morbidity.

Tramadol, meperidine, dextromethorphan, and methadone are contraindicated in patients on MAOIs as they are at high risk for causing serotonin syndrome.[8]

In general, SSRIs, SNRIs, TCAs, bupropion, mirtazapine, St. John's Wort and, sympathomimetic amines, including stimulants, are contraindicated with MAOIs.[8]